Dosing › Zepbound vials

Zepbound vials

The two kinds of Zepbound vial, how many units each dose is, and what you need to draw it.

Medical review: pendingUpdated 13 Oct 20262 scientific references

Key facts

  • A single-dose vial holds one dose in 0.5 mL: 50 units on a U-100 syringe, at every strength.
  • A multi-dose vial holds four doses of 0.6 mL: 60 units each.
  • Syringes and needles are not included; use a new one for every dose.
  • Self-pay: $299 at 2.5 mg, $399 at 5 mg, $449 from 7.5 mg with refills within 45 days.

Single-dose and multi-dose vials

Single-dose vialMulti-dose vial
Doses inside14
Each dose0.5 mL0.6 mL
On a U-100 syringe50 units60 units
After first useSingle useThrow away after 30 days or 4 doses
Out of the fridgeUp to 21 daysUp to 30 days unopened
Check which one you haveThe same dose is 50 units from one and 60 units from the other. Read the carton before every new box.

Concentration by strength

Every dose comes in the same volume, so the concentration rises with the strength:

StrengthSingle-dose pen / vialMulti-dose vial / KwikPen
2.5 mg5 mg/mL4.17 mg/mL
5 mg10 mg/mL8.33 mg/mL
7.5 mg15 mg/mL12.5 mg/mL
10 mg20 mg/mL16.7 mg/mL
12.5 mg25 mg/mL20.8 mg/mL
15 mg30 mg/mL25 mg/mL

What you need for a vial

The label asks for a syringe appropriate for the dose, such as a 1 mL syringe that can measure 0.5 or 0.6 mL, and a new syringe and needle for every injection. They are bought separately. Used syringes go straight into a sharps container.

Units calculator

Tirzepatide units calculator U-100 insulin syringe
mg
mg/mL
50units · 0.5 mL
How it worksunits = dose ÷ concentration × 100. A branded single-dose vial is always 0.5 mL (50 units) and a multi-dose vial 0.6 mL (60 units). Pens need no syringe.
It does notsuggest a dose or tell you when to increase it. That is your prescriber’s decision.

What Zepbound vials cost

Through Lilly’s self-pay programme the vial and the KwikPen share one price tier: $299 for a month at 2.5 mg, $399 at 5 mg and $449 at 7.5 mg and above, as long as each refill is completed within 45 days. Lilly notes that 2.5 mg is a starting dose, not a maintenance dose. Read 13 Oct 2026.

Getting Zepbound prescribed

Frequently asked questions

How many units is a Zepbound vial dose?

50 units from a single-dose vial (0.5 mL) and 60 units from a multi-dose vial (0.6 mL), at every strength.

Do Zepbound vials come with syringes?

No. Use a syringe suited to the dose, such as a 1 mL syringe, and a new syringe and needle for every injection.

How much does a Zepbound vial cost?

Through Lilly's self-pay programme, $299 at 2.5 mg, $399 at 5 mg and $449 at 7.5 mg and above with refills within 45 days (read 13 Oct 2026).

How long does an opened multi-dose vial last?

Throw it away 30 days after first use or after 4 doses, whichever comes first.

Scientific references

  1. Eli Lilly and Company. ZEPBOUND (tirzepatide) prescribing information. DailyMed, 2026.
  2. Eli Lilly and Company. Zepbound coverage and savings (self-pay prices). Read 13 Oct 2026.

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